Uthman appointed Ali his successor when he died but the Bakr family tried to prevent Ali's Proto-Karaite Ulu l-Amr from becoming Persia's rulers. Although Ulu l-Amr was not overthrown, western Quraysh under Muawiya seceded Syria from the Empire.
Quraysh and proto-Karaite Bakr family allies go to war against the Gnostic Noahite Eli Proto-Karaite Alids in the Battle of the Camel.Ali defeats the Bakr family but the Quraysh retain control in Syria